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This compound is not approved by the MHRA or FDA for self-administration or clinical use outside of approved clinical trial frameworks

Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025

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Diarrhea: Affects 18 to 25% of participants

IGF-1 pathway activation also intersects with regulatory networks influencing myostatin-associated signaling, contributing to modulation of anabolic gene transcription profiles in experimental models