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EHMES-1 cells were stimulated by the respective dimeric macrocycles and the phosphorylation level was quantified by enzyme-linked immunosorbent assay (ELISA) using a rabbit pY1234/1235-specific mAb

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A remarkable trait of sermorelin is its ability to elongate the peaks of growth hormone levels while also boosting the lower or "trough" levels without pushing these peaks to excessively high, unnatural extents

If no adverse events occur and target biomarkers remain unchanged, the dose escalates to 200mcg for the next 710 day interval