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Oxidized mitochondrial DNA activates the nlrp3 inflammasome during apoptosis

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Interestingly, STING-dependent signaling events, including phosphorylation of TANK-binding kinase 1 (TBK1) and transcription factor interferon regulatory factor 3 (IRF3) as well as induction of IFN-Is, can be blocked through disrupting ER to Golgi STING transport (98, 99)