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Some studies suggest a biphasic pattern, with an early peak followed by a nadir and a second rise in GLP-1 concentrations [23], but other studies in humans tend to describe monophasic secretory responses [12, 24, 25]

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Factors such as the type and severity of pain, patient comorbidities, and potential drug interactions should guide the choice of alternative treatments

Parrinello et al 166 compared the shape of the great toenail with the base of the distal phalanx and found a significant correlation between the shape of the proximal aspect of the nail plate and the shape of the phalangeal base