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Phys Act Nutr 27(2):812 [DOI] [PMC free article] [PubMed] [Google Scholar] 60.Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A (2022) Effect of Curcumin supplementation on exercise-induced muscle damage: a narrative review

Mechanistically, CYB5R can transfer electrons from NADH to O 2 , leading to H 2 O 2 production and ultimately triggering ferroptosis [29]

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The reality is that that what the FDA means by safety is a matter of regulatory compliance (large scale clinical trials, manufacturing standards, etc.) not toxicity