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It binds both receptors but produces a stronger functional response at GIPR than at GLP-1R compared with the native ligands, which is part of why it behaves differently from a balanced co-agonist
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The same active ingredient, tirzepatide, is available under the brand name Zepbound for chronic weight management
Wegovy (semaglutide) injection - Prescribing Information
Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease
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