retatrutide dosage per week Dosing Guide: 1-12 mg Weekly Triple Agonist (2026) Tirzepatide vs. Retatrutide: Key Differences

It causes the blood vessels to secrete substances that are pro-inflammatory and encourage clots

If you do all those other things, youll lose 15% of your body weight, WITHOUT the GLP-1

For practical context: a 220 pound Canadian starting both medications would expect to lose roughly 10 pounds on Orlistat versus 53 pounds on Retatrutide over similar timeframes

Persistent worsening beyond several weeks, or anything more significant than mild redness or textural change, is a reason to pause and reassess rather than push through

It is also effective with calming and hydrating ingredients to ensure that it does not parch the skin