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High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs

Chemically speaking, it comes from the attachment of sorbitan (a dehydrated sorbitol (sugar) molecule) with the fatty acid Stearic Acid, that creates a partly water (the sorbitan part) and partly oil soluble (stearic part) molecule

Specifically, the activated receptor possibly engages a class of G proteins referred to as Gq/11, which in turn may stimulate an enzyme called phospholipase C (PLC)

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Improved production of Humira antibody in the genetically engineered Escherichia coli SHuffle, by co-expression of human PDI-GPx7 fusions