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Transport and disposition of uric acid in the brain The concentrations of UA are, as mentioned, substantially lower in the CSF than in peripheral blood, indicating that UA does not rapidly equilibrate across the BBB and that there may be active transport mechanisms influencing CNS UA

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We derived a shortlist of candidate targets by subsetting the list to those enzymes listed as tier-1 targets at least once for each data set and reported as interaction partners of the proteome of at least two of the three viruses (39 candidates)