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This positions MRI iron mapping as a clinical surrogate for tissue environments prone to ferroptosis

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In AD, elevated expression of Fas and FasL increases keratinocyte vulnerability to IFN--induced apoptosis (Rebane et al., 2012), thereby contributing to skin barrier breakdown and exacerbation of eczematous inflammation (Szymanski et al., 2018)

As the primary redox buffer, it regulates the ratio between its oxidized form (GSSG) and reduced form (GSH), which determines the entire cellular redox environment