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Currently, the treatment options for L2HGA include a protein-restricted diet, application of antiepileptic therapeutic drugs for symptomatic treatment, and supplementation of riboflavin and carnitine (such as L-carnitine)

These side effects are typically mitigated by starting at a low dose, but they can recur when the dose is increased, presenting a risk to patient adherence

doi: 10.1038/s41596-022-00738-y 48 MaedaK.OkudaY.EnomotoG.WatanabeS.IkeuchiM

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a , IL-6 expression in Raw264.7 cells after P1, P5, or P9 treatment (10 g ml 1 ) overnight