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This damage compromises membrane integrity, affecting cellular signaling and transport functions

These reactions are usually mild to moderate, appear early in treatment or after a dose increase, and often become less noticeable over time

Histologically, besides hyperpigmentation of basilar keratinocytes, lentiginous melanocytic hyperplasia may be observed in association with marked secondary epidermal rete hyperplasia, sometimes simulating the appearance of a reticulated seborrheic keratosis

Moisturizing is an essential step in a skin care routine to reduce melanin pigmentation

The injection site should be rotated to prevent lipohypertrophy or lipoatrophy, which are changes in subcutaneous fat that can affect absorption