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Addresses the metabolic dysfunction driving fat storage

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The anorectic effects of GLP-1 appear to be mediated largely by the hypothalamic arcuate nucleus, which contains anorexigenic pro-opiomelanocortin and orexigenic neuropeptide Y/Agouti-related peptide (AgRP) neurons [51]

Cardiovasc Diabetol 21(1):169 Nauck MA, Meier JJ (2019) Management of endocrine disease: Are all GLP-1 agonists equal in the treatment of type 2 diabetes

Clonidine acts on the central nervous system to reduce blood pressure, while propranolol is a beta-blocker that affects heart rate and vascular resistance