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This functional activity is supported by a multitude of studies demonstrating that anti-inflammatory M2-like macrophages are induced in various models of pancreatic injury and inflammation and operate to promote -cell survival, proliferation, and maintenance of functional -cell mass, through the release of protective factors, such as IGF-1, epidermal growth factor (EGF), transforming growth factor (TGF), platelet-derived growth factor (PDGF), and Wnt3a (78)
The primary objective was to determine whether dapagliflozin 10 mg reduces the incidence of the composite endpoint of 50% sustained decline in eGFR, progression to end-stage kidney disease (ESKD) (defined as sustained eGFR 40% and evidence of structural heart disease to determine whether dapagliflozin reduces the risk of cardiovascular death, hospitalization for heart failure or urgent heart failure visits
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Fertility changes: Weight loss can sometimes improve ovulation, which might make pregnancy more likely
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