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** Survey of 291 adults who self-reported that they felt lighter and more energetic after completing the Metamucil Two Week Challenge

If your MTHFR gene mutation reduces folate metabolism, the risk of pregnancy complications rises significantly, including neural tube defects (spina bifida, cleft lip/palate), Down syndrome, preeclampsia, recurrent losses and more

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Active malignancy is a contraindication because NAD+ supports cellular proliferation

yet, more future research and large clinical trials are needed on varied populations to establish the facts and make metformin an established drug for various diseases