Systemic side effects are rare at low doses, with transient nausea or mild headache reported infrequently
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However, adverse alterations in mtDNA copy number or integrity are closely associated with the development of metabolic diseases, such as diabetes (86)
Any assertion to the contrary is not supported by evidence It IS fair to say that there is no clear evidence of harm in a relatively data free zone in humans, and that there is a plausible argument for benefit based upon in vitro and animal studies as well as mechanism of action - particularly with BPC
Drug-Drug Interactions and Contraindications: Clinical trials failed to identify any significant interactions, other than those affecting Sitagliptin pharmacokinetics, which could potentially impact the dose [31]
