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What are the Vitamin B12 Injection Benefits

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If you are self-supplementing with high-dose B12 without medical indication, discuss this with your GP

Chronic gut dysbiosis and endotoxin exposure increase circulating pro-inflammatory cytokines, which activate endothelial cells and upregulate adhesion molecules such ICAM-1, VCAM-1, E-selectin, and P-selectin on the brain microvascular endothelium [125]

Thus, platelet activation may be associated with several factors, including abnormal RBCs, RBC exposed phophotidylserine, micropartcles, hemolysis, iron overload and ROS resulting in chronic platelet activation and hypercoagulability in -thalassemia/HbE patients (Fig