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Can they induce 3A4 like carbamazepine does

[1] [3] These combined effects lead to decreased caloric intake and significant weight loss in clinical trials

Patients should seek care if they develop severe muscle pain or marked weakness that impacts daily function

Average body weight reduction: 5 mg weekly: 16.0% reduction (approximately 35 pounds for a 220-pound person) 10 mg weekly: 21.4% reduction (approximately 47 pounds) 15 mg weekly: 22.5% reduction (approximately 50 pounds) Placebo: 2.4% reduction Percentage of participants achieving clinically significant weight loss: 5% or more weight loss: 85% at 5 mg, 89% at 10 mg, 91% at 15 mg 10% or more weight loss: 69% at 5 mg, 78% at 10 mg, 84% at 15 mg 20% or more weight loss: 32% at 5 mg, 49% at 10 mg, 57% at 15 mg Look at those numbers carefully

Elevations of liver enzymes to more than 3 times the upper limit of normal warrant dose hold and hepatology consultation