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van der Hee and Wells, 2021)

Many arginase inhibitors with high affinity have been developed over the past several decades, such as N-hydroxy-L-arginine [NOHA, K i = 3.6 M for human ARG1 (Di Costanzo et al., 2010), 1.6 M for human ARG2 ( d = 0.47 M for human ARG1 (Di Costanzo et al., 2010), 51 nM for human ARG2 ( 50 values of derivatives range 171,470 nM for human ARG1, 302,150 nM for human ARG2 (Ilies et al., 2011)] and S-(2-boronoethyl)-l-cysteine (BEC) [K i = 0.40.6 M (Pudlo et al

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1115,1116 Oligonucleotides and small interfering RNAs (siRNAs) modulate pre-mRNA splicing or neutralize microRNAs, increasing the expression of energy-producing genes that are often downregulated in neurodegenerative conditions

10.1016/j.expneurol.2019.113028 75 LiJ.-Y.RenC.WangL.-X.YaoR.-Q.DongN.WuY.et al (2021)