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Across the STEP trials that enrolled non-diabetic participants, mean weight loss on semaglutide 2.4 mg ranged from 14.9% (STEP 1, medication alone) to 16.0% (STEP 3, medication plus behavioral therapy) at 68 weeks [1][2]

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Duration of application: The drug is intended for prolonged use

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These changes reduce its binding affinity to IGF-binding proteins (IGFBPs), allowing for a longer half-life (up to 2030 hours) and increased bioavailability in plasma