glp 1 discovery Discovery, characterization, and clinical development of the glucagon-like peptides Frontiers | GLP-1 receptor agonists:

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Non-targeted metabolomics analyses showed that platinum-resistant ovarian cancer cells have significantly reduced levels of GSH, which contributes to chemoresistance by forming adducts with cisplatin, leading to reduced intracellular concentrations of the active drug, and cisplatin-GSH adducts also reduce intracellular GSH levels

In addition, a greater effect of tirzepatide on dose-dependent body weight reduction versus semaglutide was observed (least-squares mean estimated treatment difference of -1.9 kg, -3.6 kg, and -5.5 kg for the three doses

The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure