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Pre-existing osteoarthritis, increased physical activity, dehydration, and weight-loss-triggered gout flares may also contribute

This provides an important tool for research into aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and offers experimental evidence for intervention strategies in neuronal aging

Clinical Effectiveness

Limited head-to-head trials directly compare topiramate-plus-GLP-1 combinations against GLP-1 monotherapy at equivalent doses