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National Institute for Health and Care Excellence (NICE)

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Tirzepatide produces slightly greater average weight loss (20-22% vs 10-15%), but both medications work through similar mechanisms

Your insurance company may require prior authorization or step therapy (a trial of less expensive weight loss medications) before approving GLP-1 drugs

What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes