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endocrine-axis modeling in animal systems as a receptor-selective pharmacology tool compound

Bile duct ligation (BDL) caused obstructive jaundice, abnormal liver function, increased lipid peroxide levels, and decreased GSH levels in rats, which indicated that oxidative stress in rats with obstructive jaundice was observed

Specifically, reduced IL-12 hampers Th1 cell differentiation and macrophage activation, reduced IL-2 compromises T-cell proliferation, and reduced IFN- impairs intracellular defense [19]

This suggests that analogs may potentially influence the fibrotic process by modulating the expressions of genes involved in fibrogenesis and inflammation

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