SELECT Trial The SELECT trial, one of the largest cardiovascular outcomes trials in obesity medicine, enrolled over 17,000 participants with established cardiovascular disease and obesity or overweight (without diabetes) and demonstrated a 20% reduction in MACE with semaglutide 2.4 mg
It means the evidence base is theoretical, anecdotal, and rooted in pharmacokinetic modeling rather than clinical outcomes data
ISBN 978-1846038198
In the STEP 1 study, 15% of semaglutide patients reported headaches compared to 12% on placebo
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