Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC et al
Nakamura Y, Suda T
By adding L-theanine to the drinking water of cirrhotic rats established by carbon tetrachloride, it was found that L-theanine inhibited the expression of NF-B, downregulated the pro-inflammatory cytokines (e.g., IL-1 and IL-6), and profibrotic mediators (e.g., transforming growth factor and connective tissue growth factor), and promoted the expression of anti-inflammatory cytokine IL-10 and fibrinolytic enzyme metalloproteinases-13 (85)
This fatigue, termed lassitude, signifies a pervasive lack of mental energy unrelated to activity level, mood disorder, or physical strength
In another embodiment, the thickened formulation or composition includes a pharmaceutically acceptable buffer