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TABLE 5 Clinical studies elucidating the use of GLP-1R agonists in Alzheimers disease and cognitive dysfunction in other conditions

This inhibition reduces NNMT-mediated nicotinamide methylation, preserving NAD+ that would otherwise be converted to inactive methyl-NAD compounds

doi: 10.3389/fpls.2025.1425880 Received 30 April 2024 Accepted 09 January 2025 Published 20 February 2025 Volume 16 - 2025 Edited by Maria Raffaella Ercolano, University of Naples Federico II, Italy Reviewed by Eva Nouri, Universit de Fribourg, Switzerland Marija Vidovic, University of Belgrade, Serbia Updates Copyright 2025 do Carmo Santos, Silva Santos, Pereira Silva de Novais, dos Santos Lopes, Pirovani and Micheli

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Individuals Over 35 After age 35, telomere shortening accelerates , and melatonin production declines