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If a vial will take more than 30 days to finish at your current dose, consider splitting the powder into multiple vials before reconstitution, or accept that the final doses may be slightly less potent

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Acknowledgements This work was supported by Chang Gung Memorial Hospital [CMRPG391311, CMRPG3A1131, CMRPG3H0611 and Grants CIRPD1D0071-3

A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)

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