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While changes in propionyl-CoA carboxylase (PCC) activity were not detected during fasting, the study revealed an enhanced gluconeogenesis process that resulted in an increased carbon flux from propionyl-CoA to glucose

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The CLOCK/BMAL1 heterodimer combines with the E-box response element which located in the promoter region to stimulate the expression of other target genes, the core of which is the transcriptional expression of other clock genes, such as Periods ( PER1 , PER2 , and PER3 ), and Cryptochromes ( CRY1 and CRY2 )

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