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Overall, the literature suggests that curcumin exerts its beneficial effects through modulation of various signaling pathways, including NF-B, NLRP3, AKAP150/PKA/PP2B, miR-146a-5p/ERK, BDNF/Trkin, ROS-ERK1/2, GABAA receptor, gut-brain axis and Keap1-Nrf2-ARE, in different disease models and conditions

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Plasma was harvested by centrifugation and stored in 70 for determination of GH