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The binding of AGEs to their receptor (RAGE) activates the AGEs/RAGE signaling pathway, inducing inflammation, oxidative stress, cell apoptosis, insulin resistance, and damage to pancreatic cells 92

Cyp3A4 dominates by having a much larger V max than the other two enzymes

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A functional peptide analogue with improved oral bioavailability can be fabricated by retaining specificity for the enzymes responsible for its bioactivity while decreasing specificity to the enzymes associated with its degradation [23]