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Edwards MH, Dennison EM, Aihie SA, Fielding R, Cooper C

Tirzepatide is FDA-approved as Mounjaro for type 2 diabetes (2022) and as Zepbound for chronic weight management (2023), and it is also approved by the EMA

Activity regulated by mechanical stress, hormones (GH, IGF-1, PTH), local growth factors (BMPs, TGF-), and inflammatory signals

Most of the CDDO-ME subjects also exhibited fluid retention with an increase in blood pressure, heart rate, and serum brain natriuretic peptide (BNP) in addition to a decrease in blood concentrations of albumin and hemoglobin compared to the placebo subjects

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