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To ensure the accuracy and sensitivity of the biochemical assessments, all ELISA kits were sourced from reputable manufacturers (Bio-Rad Laboratories, USA

The key challenges include high production costs, low yield, high voltage requirements, clogging, and the use of toxic materials in complex techniques

Their translational use is shaped by tissue penetration, lesion depth, light accessibility and the need for specialized activation devices, making them more suitable for superficial, endoscopically accessible or intraoperatively exposed lesions [73, 104]

The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease