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After comparing NR with NA and NAM in mice, NR showed a significant higher peak of NAD + concentration and a significant increase of intermediate NAD + precursors including NMN, NA mononucleotide and NA adenine dinucleotide (Trammell et al., 2016) (Table 2)

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This synergy suggests that combination approaches may be advantageous, with hyaluronic acid providing lubrication and chondroprotection while AOD-9604 supports tissue regeneration

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Prediabetes increases the risk of frailty in prefrail older adults with hypertension: beneficial effects of metformin