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In vitro , ICA effectively attenuated the IL-1 induced suppression of SLC7A11 and GPX4 expression in SW1353 cells, restored intracellular levels of ROS, lipid peroxides, and MDA, and significantly reduced erastin induced ferroptosis

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To protect themselves from irreversible damage and prevent the cell from undergoing apoptosis (programmed cell death), the mitochondria initiate a defensive mechanism known as the Cell Danger Response (CDR)