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In 1983, Bell and colleagues cloned the human proglucagon gene, revealing the sequences of GLP-1 and GLP-2

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However, these approaches face critical delivery challenges, including poor tumor penetration, rapid systemic clearance, and off-target toxicity, necessitating nanomaterials-mediated targeted delivery systems to achieve tumor-specific accumulation and enhanced therapeutic precision

There are studies demonstrating that taurine has pro-apoptotic effects on human colorectal cancer cells [50], inhibits lung metastasis in breast cancer in mice, and attenuates anthracene-induced breast tumorigenesis in mice [51, 52]

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