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Our analysis included a matched treatment and control cohort that was followed longitudinally for a minimum of 12 months, with a rich range of covariates from source-of-truth clinical data to match patients with a machine learning approach that allowed for strong overlap between the treatment and control cohorts

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In the past few years, there have been reports linking the condition to GLP-1 drugs like semaglutide and tirzepatide

Theres a black box warning against use in people with personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Unlike traditional medical trend drivers, such as hospital price increases or incremental pharmaceutical innovations, GLP-1 agonists combine rapid uptake, significant per-patient costs, and uncertain long-term offsets