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Pontarollos team (102) has revealed a novel mechanism by which gut microbiota modulate intestinal barrier function: symbiotic bacteria activate TLR-2 signaling in the innate immune receptors of intestinal epithelium, thereby downregulating neuropilin-1 (NRP1) and the Hedgehog signaling pathway it regulates, thus impairing intestinal barrier function

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H&E staining revealed that EMs and EMs with iron overload resulted in abnormal follicle development, while deferoxamine mesylate and VITE ameliorated the abnormal follicle development induced by high iron (Fig