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Some natural medicines, such as curcumin, sinomenine, andrographolide, emodin and GCK, can get better therapeutic effects and/or less side effects when being used in combination with MTX for the treatment of RA

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Compounding gastrointestinal side effects (severe nausea, vomiting, dehydration), increased hypoglycemia risk, unpredictable drug-drug interactions, and complete absence of safety data

It also improved muscle function and body composition