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Exendin-4treated Ldlr / mice on an HCD not only showed smaller atherosclerotic lesions but also a more than 50% reduction in blood leukocytes, including Ly-6C hi monocytes and neutrophils (7), suggesting downregulation of bone marrow hematopoiesis in response to activation of the GLP-1R

These changes are often due to decreased endogenous hormone levels

Goldsmith, Andrew J., et al

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Furthermore, recent data indicates effectiveness in inhibiting fibrosis advancement, with clinical studies revealing markedly reduced progression rates in individuals treated with semaglutide (5%) compared to placebo groups (19%) (Newsome et al