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Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial

Kristin Baier, Calibrate's vice president of clinical development, in an interview

The results have been submitted for peer-reviewed publication

Additionally, for the cerebrovascular uptake study treatment was added as repeated variable