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The potential dangers of long-term use that have not manifested in short-term research remain ambiguous

Use of drugs that inhibit organic cation transporter 1 activity (including tricyclic antidepressants, citalopram, proton-pump inhibitors, verapamil, diltiazem, doxazosin, spironolactone, clopidogrel, rosiglitazone, quinine, tramadol and codeine) increased intolerance to metformin (72)

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Although further studies on secreted exosomal SELENOP are required, the exosomal transport of selenoprotein through BBB to neuronal cells might be an alternative route for Se delivery into the brain

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