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Potentiation of neuronal differentiation, promotion of cell survival, up-regulation of neurotransmitter synthesis and modulation of glial cells are other functions of GLP-1 in CNS that have been reported, while more diseases such as Huntingtons disease , stroke , and peripheral sensory neuropathy potentially become its therapeutic targets
The effect may be seen within 30 minutes or it may be several hours
Nonetheless, different animal models deficient for GLP-1 signaling, in addition to human studies, prove the dispensability of GLP-1 for surgical success ( On the other hand, PYY has been proven to be upregulated, and necessary, for RYGB mediated restoration of the diabetic islets, and overall cure of diabetes in rats (154)
These symptoms may indicate that the combination of Mounjaro with metoprolol or Mounjaro with carvedilol is causing unwanted effects that require medication adjustments
