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Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations

Moreover, WCG data reveals that budget negotiations alone can stretch nine-plus weeks, even though only a small fraction of that time involves active review often referred to as white space, or waiting time in the workflow exposing a hidden bottleneck in site workflows

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