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Because Dihexa promotes structural changes in synaptic density and neural connections, effects often persist beyond treatment duration, allowing for cycling approaches rather than continuous use

They exert these protective effects partly by activating the cAMP-CREB signaling pathway and regulating downstream gene transcription

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The precise mechanism may involve multiple processes including compensatory receptor crosstalk and it is to be further investigated

The majority of subjects in both groups experienced either no or mild improvement