The GLP-1 diet approach works best when combined with nutritious foods that support the medications effects something many doctors dont adequately explain to patients
In the subgroup without SGLT2i use at baseline, those numbers were 290/1,490 (19.5%) versus 372/1,493 (24.9%) for semaglutide and placebo groups, respectively (HR 0.73
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
It is composed of three peptides: glutamic acid, cysteine, and glycine
Evidence supports: Low glycemic index/glycemic load eating pattern: Reduces insulin and IGF-1 signalling, and supports healthy weight, which reduces aromatase-driven estrogen production Increased intake of cruciferous vegetables: Provide DIM (diindolylmethane) precursors that support Phase I/II estrogen metabolism Omega-3 fatty acids: EPA/DHA reduce pro-inflammatory prostaglandin production (PGE2), relevant to heavy bleeding Reduced alcohol: Alcohol raises estradiol levels and impairs hepatic estrogen clearance Food sensitivity identification: Chronic dietary-driven intestinal inflammation can contribute to systemic inflammatory load
