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Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Significant enrichment of genes involved in the MAPK signaling pathway was observed (e.g., MAP3K5, MAPK11, PDGFRB, RASGRF1)

Corticotropin-releasing hormone and the sympathoadrenal system are major mediators in the effects of peripherally administered Exendin-4 on the Hypothalamic-Pituitary-Adrenal axis of male rats

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