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Microscopic molecular pores in the collecting ducts can selectively allow water to be pulled out of the ducts and retained in the body (Baynes 2014
Epub 12011 Nov 10517
Quantitative analysis of GLP-1 receptor occupancy in the pancreas (graph to the left above) showed a clear decrease in PET signal from baseline ( blue markers) to 3 weeks post up-titration of the GLP-1/glucagon peptide ( red markers), indicating a receptor occupancy of around 50%
Tirzepatide slows gastric emptying by activating these neurons, reducing postprandial glucose spikes and attenuating hunger signals relayed to the nucleus tractus solitarius (NTS) [13]
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