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Dysregulated iron metabolism, including increased expression of transferrin receptors and ferritin degradation, leads to iron accumulation, contributing to ferroptosis ( 2+ acts as a cofactor for LOXs and prolyl hydroxylase, which are critical enzymes involved in lipid peroxidation and oxygen homeostasis ( During the first trimester, hepcidin levels increase, while in the second trimester, hepcidin levels decrease despite stable serum iron levels

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Zinc prevents the intestines from absorbing copper

doi: 10.3390/biology8020028 171 SainiR

Furthermore, based on mechanistic insights, the review explores targeted gut microbiota interventions, systematically evaluating clinical evidence for dietary modifications, probiotic/prebiotic supplementation and fecal microbiota transplantation