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Under hypoxia, enhanced anaerobic metabolism leads to the accumulation of acidic substances, such as lactic acid, and an increase in the microenvironment pH
Ultimately, we anticipate that the continued development of precise and effective senotherapeutic interventions will lead to the targeted elimination of senescent cells, their detrimental SASP, and improved health outcomes in age-related diseases such as AD
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Thereafter, cortisol values decline throughout the day 2,10,11
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